‘... a curious condition which consists in a difference in the pigmentation of the two eyes...', '...regarded by the casual observer as a play or caprice of nature.'  Mutiple genes are responsible for variations in a person's eye color. With semi-curly, shortish auburn-blonde hair, Thomas turned to look at me. ‘Look at his eyes!’ My friend proclaimed. ‘Look! His two eyes are different!' What is it? I asked. ‘They’re different colors!’ A strong jaw announced Thomas’ physical dominance in height and strength. Thomas, froze momentarily as I curiously turned upward to this giant - almost as tall as the doorway. Indeed, his eyes were different colors. Slate blue, and as obvious as his now furrowed expression, jade-green-hazel in the other. Gene Heritage is an online DNA service allowing you to upload your raw data from AncestryDNA, FamilyTreeDNA, 23andMe to compile reports about your family's genes, traits such as blue eyes, and a gene's ancient origins. Gene Heritage helps you to create an insightful picture of your physical identity and your genetic inheritance. It is one player that aims to improve our understanding of ourselves. I previously covered Gene Heritage here and here. Gene Heritage tests for nearly twenty genetic traits that influence who you are, including your eye color, perceptions of taste, sensitivity to smell and reactions to alcohol. Gene Heritage is offering you an insight into how you may have inherited certain traits not just from your parents but your grandparents too. You can build three-generation genetic family trees which show which genes have been passed down to a grandchild and the percentage of DNA a grandchild inherited from each grandparent. Joseph Silver, creative director and co-founder of Gene Heritage says, ‘The Grandchild Report reveals what percentage of DNA a grandchild inherited from each grandparent.' He adds, 'As you may know already, it’s not necessarily a 25/25/25/25 split. While a Grandchild Report can be generated with as little as 1 grandparent, 1 parent, and a grandchild, best results are achieved with more family members.’ If you have already uploaded your own DNA test result from AncestryDNA you can upload and purchase a report from Gene Heritage. Each report costs $8 per family member. Below are examples of a Gene Heritage grandparent-child report:  Gene Heritage is able to show you how much of your DNA you inherited from your parents and grandparents. It’s easy to assume that you inherit a quarter of your genes from each grandparent, but realistically this is to a matter of degree. Source: Gene Heritage  With more DNA information on parents and grandparents uploaded to Gene Heritage, the better your DNA inheritance report will be. Source: Gene Heritage To assist you Gene Heritage also has easy-to-understand explainers of each gene detected in your DNA, all of which are referenced:  In this example, Gene Heritage reports Jean inherited one "Light" allele of OCA2 from Rosalind, and inherited one "Dark" allele of OCA2 from Gregor. Source: Gene Heritage  Gene Heritage explains that, ‘blue, green, and grey eyes are lighter and contain less melanin. Hazel eyes are in the middle of the dark-light spectrum. Brown eyes have higher concentrations of melanin. Certain mutations in OCA2 lead to albinism, of which one trait is blue eyes.’ Source: Gene Heritage Thomas, my high school colleague in my opening story likely had heterochromia. Heterochromia iridium (or binocular heterochromia) refers to a condition in which the iris in one eye has a different color the other. While the condition can be acquired (because of an injury to the eye), it can also be inherited due to variations in a major gene, OCA2. (This website briefly explains all the types and possible causes of heterochromia.) There are famous living and historical figures with heterochromia. Actress Kate Bosworth and actor Henry Cavill have heterochromia. American ophthalmologist described heterochromia in 1918 as a, ‘...curious condition which consists in a difference in the pigmentation of the two eyes...', '...regarded by the casual observer as a play or caprice of nature.' Even Anastasius I, a Byzantine Emperor from years 491 to 518 had separately colored eyes and was also thought to have heterochromia.  In 2008, a team of scientists at the University of Copenhagen suggested that a genetic mutation in the OCA2 gene that took place 6-10,000 years ago is the cause of all blue eyes. Even if you don't have heterochromia (given that it is quite a rare condition), knowing where your blue eyes came from is definitely satisfying. Ever since testing my DNA with AncestryDNA, I am informed about my health and family history. I anticipate that this priceless information may eventually be part of everyday living. To get your own Gene Heritage report, visit http://www.geneheritage.com/
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Wretched, terrible, destructive year, the remnants of the people alone remain." 
An infected aeroplane passenger could bring a pandemic across the world in less than 24 hours. Such is the speed and convenience of air travel. The International Air Transport Association (IATA) estimated that 4 billion passengers used aviation in 2017 alone.
It was the international disease gripped planet Earth during the Middle Ages. In just four years, from 1341 to 1351, the Black Death killed up to 200 million people in Europe, with the disease steadily advancing west across the Continent. As a fifteen-year-old, princess Joan of England was to be betrothed to Peter of Castile. As Joan of England disembarked at Bordeaux she ignored the warnings of Bordeaux’s mayor, Raymond de Bisquale that the Black Death had gripped Bordeaux.
The royal castle where the princess and her entourage had lodged were surrounded by hundreds of decomposing corpses of the pestilence. Those still in the Black Death's grip showed tell-tale signs of infection: buboes, often painful and swollen lymph nodes as large as chicken eggs under the armpits. Those sick people were coughing up blood, lying prostrate from the fatigue of struggling with the plague before collapsing and dying in the street. You can head to Promethease if you want to know what other genes you have."  Gregor Johann Mendel (1822 – 1884) was a scientist whose seminal work on breeding pea plants (Pisum sativum) underpins our modern understanding of genetic inheritance. What can I do with my raw AncestryDNA file?
I’ve noticed that one of the benefits of undertaking an AncestryDNA test is the ability to download the raw data. I’ve used this feature several times including uploading it to MyHeritage DNA, DNA.Land and to Promethease. You can expect over time for all of these consumer DNA companies to offer more and more analysis of your DNA sample. (I previously compared AncestryDNA and DNA.Land here, and my view on MyHeritageDNA is here. My review of Gene Heritage is also here.) |
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